Product Name :
Rodatristat
Description:
Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice.
CAS:
1673568-73-4
Molecular Weight:
561.98
Formula:
C27H27ClF3N5O3
Chemical Name:
(3S)-8-2-amino-6-[(1R)-1-5-chloro-[1,1′-biphenyl]-2-yl-2,2,2-trifluoroethoxy]pyrimidin-4-yl-2,8-diazaspiro[4.5]decane-3-carboxylic acid
Smiles :
NC1N=C(C=C(N=1)N1CCC2(C[C@H](NC2)C(O)=O)CC1)O[C@H](C1=CC=C(Cl)C=C1C1C=CC=CC=1)C(F)(F)F
InChiKey:
ZNSPHKJFQDEABI-NZQKXSOJSA-N
InChi :
InChI=1S/C27H27ClF3N5O3/c28-17-6-7-18(19(12-17)16-4-2-1-3-5-16)23(27(29,30)31)39-22-13-21(34-25(32)35-22)36-10-8-26(9-11-36)14-20(24(37)38)33-15-26/h1-7,12-13,20,23,33H,8-11,14-15H2,(H,37,38)(H2,32,34,35)/t20-,23+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Flurbiprofen Apoptosis
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice.E 2012 manufacturer |Product information|CAS Number: 1673568-73-4|Molecular Weight: 561.98|Formula: C27H27ClF3N5O3|Chemical Name: (3S)-8-2-amino-6-[(1R)-1-5-chloro-[1,1′-biphenyl]-2-yl-2,2,2-trifluoroethoxy]pyrimidin-4-yl-2,8-diazaspiro[4.PMID:33089743 5]decane-3-carboxylic acid|Smiles: NC1N=C(C=C(N=1)N1CCC2(C[C@H](NC2)C(O)=O)CC1)O[C@H](C1=CC=C(Cl)C=C1C1C=CC=CC=1)C(F)(F)F|InChiKey: ZNSPHKJFQDEABI-NZQKXSOJSA-N|InChi: InChI=1S/C27H27ClF3N5O3/c28-17-6-7-18(19(12-17)16-4-2-1-3-5-16)23(27(29,30)31)39-22-13-21(34-25(32)35-22)36-10-8-26(9-11-36)14-20(24(37)38)33-15-26/h1-7,12-13,20,23,33H,8-11,14-15H2,(H,37,38)(H2,32,34,35)/t20-,23+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Rodatristat (10-50 mg/kg; oral administration; mice) treatment decreases intestinal 5-HT concentrations at 50 mg/kg, their efficacy drop off significantly at the lower 10 mg/kg dose.|Products are for research use only. Not for human use.|
