Product Name :
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid
Description:
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
CAS:
846549-37-9
Molecular Weight:
554.59
Formula:
C22H42N4O12
Chemical Name:
2-{[(26-azido-3, 6, 9, 12, 15, 18, 21, 24-octaoxahexacosan-1-yl)carbamoyl]methoxy}acetic acid
Smiles :
[N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)COCC(O)=O
InChiKey:
WWDNBBVPYDZICO-UHFFFAOYSA-N
InChi :
InChI=1S/C22H42N4O12/c23-26-25-2-4-31-6-8-33-10-12-35-14-16-37-18-17-36-15-13-34-11-9-32-7-5-30-3-1-24-21(27)19-38-20-22(28)29/h1-20H2,(H,24,27)(H,28,29)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.|Product information|CAS Number: 846549-37-9|Molecular Weight: 554.59|Formula: C22H42N4O12|Chemical Name: 2-{[(26-azido-3, 6, 9, 12, 15, 18, 21, 24-octaoxahexacosan-1-yl)carbamoyl]methoxy}acetic acid|Smiles: [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)COCC(O)=O|InChiKey: WWDNBBVPYDZICO-UHFFFAOYSA-N|InChi: InChI=1S/C22H42N4O12/c23-26-25-2-4-31-6-8-33-10-12-35-14-16-37-18-17-36-15-13-34-11-9-32-7-5-30-3-1-24-21(27)19-38-20-22(28)29/h1-20H2,(H,24,27)(H,28,29)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (180.31 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.{{Toripalimab} MedChemExpress|{Toripalimab} PD-1/PD-L1|{Toripalimab} Purity & Documentation|{Toripalimab} In Vivo|{Toripalimab} supplier|{Toripalimab} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Atropine} medchemexpress|{Atropine} Neuronal Signaling|{Atropine} Protocol|{Atropine} Data Sheet|{Atropine} supplier|{Atropine} Cancer} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PMID:32644608 PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|References:|An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562Products are for research use only. Not for human use.|
