Icetin, morin 3,45trimethoxytransstilbene, piceatannol resveratrol, pinostilbene, pterostilbene, Flavan3ols Stilbenoids ()catechin, taxifolin, ()epicatechin, ()epicatechin gallate, three,4 5trimethoxytransstilbene, piceatannol (Flavanols) ()epigallocatechin gallate, ()gallocatechin gallate ()catechin, taxifolin, ()epicatechin, ()epicatechin Isoflavones (Flavanols) genistein Flavan3ols gallate, ()epigallocatechin gallate, ()gallocatechin gallate Flavanones naringenin genistein Phenolic Isoflavones acids caffeic acid, transferulic acid, chlorogenic acid Flavanones naringenin Catechin M1, M2 metabolites acids Phenolic caffeic acid, transferulic acid, chlorogenic acid Ellagic acid and Catechin metabolites M1, M2 ellagic acid, urolithin A, B, C, D its metabolitesTable 1. List of polyphenolic compounds and intestinal microbiotagenerated metabolites incorporated in Chemical Person Compounds Quantity the screening with regards to their effects on phosphorylation of Akt at Ser473 website. Classification according Subclass to Zhang et al. 2016 [2]. Number551 61 three 12Ellagic acid and its metabolites ellagic acid, urolithin A, B, C, D 5 Subclasses and representatives, which were also investigated by Western blot evaluation, are Subclasses and representatives, which were also investigated by Western blot evaluation, are marked in bold. marked in bold.()Catechin, ()epicatechin, ferulic acid, M2, naringenin and all investigated glycosides ()Catechin, ()epicatechin, ferulic acid, M2, naringenin and all investigated glycosides (vitexin, (vitexin, wogonoside, baicalin) exhibited a nonstatistically significant tendency to slightly augment wogonoside, baicalin) exhibited a nonstatistically Bensulfuron-methyl In Vitro substantial tendency to slightly augment pAkt Ser473. pAkt Ser473.Figure three. Polyphenols from distinctive subclasses displaying a lot more pronounced pAktinhibition. The columns Figure three. Polyphenols from distinct subclasses showing extra pronounced pAktinhibition. The represent implies of your residual phosphorylation (in ) with common deviations. Statistically considerable columns represent means with the residual phosphorylation (in ) with typical deviations. inhibitions have been observed for the flavones luteolin and apigenin, the flavonols fisetin and quercetin, Statistically significant inhibitions were observed for the flavones luteolin and apigenin, the the dibenzopyrone urolithin A as well as the stilbenoid Chiauranib Epigenetic Reader Domain resveratrol (n = three), p 0.01. The difference flavonols fisetin and quercetin, the dibenzopyrone urolithin A and also the stilbenoid resveratrol (n = in between theeffects The difference resveratrol was statistically important as well, was0.01 (oneway of luteolin and among the effects of luteolin and resveratrol p statistically 3), p 0.01. ANOVA with Tukey p 0.01 (oneway ANOVA with Tukey HSD test). substantial at the same time, HSD test).Biomolecules 2019, 9,Biomolecules 2019, 9,eight of8 ofStatistical substantial effects of luteolin, urolithin A, apigenin, quercetin, fisetin, and resveratrol Statistical substantial effects of luteolin, urolithin A, apigenin, quercetin, fisetin, and resveratrol (p = 0.001) have been determined by oneway ANOVA using the Tukey HSD test [42]. The statistical (p = 0.001) had been determined by oneway ANOVA with all the Tukey HSD test [42]. The statistical analysis also revealed a statistically significant difference in between the effects of luteolin and resveratrol analysis also revealed a statistically substantial distinction involving the effects of luteolin and (presveratrol (p = 0.0.
