Blots are shown in the upper right hand corner. Lane 1 represents
Blots are shown in the upper right hand corner. Lane 1 represents sham group; Lane 2 represents vehicle control group; Lane 3 represents TMP group. The bars depict densitometry analyses of Western Blots from four independent experiments. Ischemia reperfusion obviously reduced Bcl-2 expression and increased Bax expression compared with the sham group. *P < 0.01, vs sham group; **P < 0.01, vs control group.mutase on spinal cord blood flow and paraplegia in baboons. Ann Surg 1986, 204:38-47. Svensson LG, Crawford ES, Hess KR, Coselli JS, Safi HJ: Experience with 1509 patients undergoing thoracoabdominal aortic operations. J Vasc Surg 1993, 17:357-368. Tabayashi K, Niibori K, Konno H, Mohri H: Protection from postischemic spinal cord injury by perfusion cooling of the epidural space. Ann Thorac Surg 1993, 56:494-498. McCullough JL, Hollier LH, Nugent M: Paraplegia after thoracic aortic occlusion: influence of cerebrospinal fluid drainage. Experimental and early clinical results. J Vasc Surg 1988, 7:153-160. Zvara DA: Thoracoabdominal aneurysm surgery and the risk of paraplegia: contemporary practice and future directions. J Extra Corpor Technol 2002, 34:11-17. Chan PH: Role of oxidants in ischemic brain damage. Stroke 1996, 27:1124-1129. Orendacova J, Marsala M, Marsala J: The blood-brain barrier permeability in graded postischemic spinal cord reoxygenation in rabbits. Neurosci Lett 1991, 128:143-146. Lin R, Roseborough G, Dong Y, Williams GM, Wei C: DNA damage and repair system in spinal cord ischemia. J Vasc Surg 2003, 37:847-858. Sakurai M, Nagata T, Abe K, Horinouchi T, Itoyama Y, Tabayashi K: Survival and death-promoting events after transient spinal cord ischemia in rabbits: induction of Akt and caspase3 in motor neurons. J Thorac Cardiovasc Surg 2003, 125:370-377. Sakurai M, Takahashi G, Abe K, Horinouchi T, Itoyama Y, Tabayashi K: Endoplasmic reticulum stress induced in motor neurons by transient spinal cord ischemia in rabbits. J Thorac Cardiovasc Surg 2005, 130:640-645. Zhang ZH, Yu SZ, Wang ZT, Zhao BL, Hou JW, PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27735993 Yang FJ, Xin WJ: Scavenging effects of tetramethylpyrazine on active oxygen free radicals. Zhongguo Yao Li Xue Bao 1994, 15:229-231. Feng L, Xiong Y, Cheng F, Zhang L, Li S, Li Y: Effect of ligustrazine on ischemia-reperfusion injury in murine kidney. Transplant Proc 2004, 36:1949-1951. Liao SL, Kao TK, Chen WY, Lin YS, Chen SY, Raung SL, Wu CW, Lu HC, Chen CJ: Tetramethylpyrazine reduces ischemic brain injury in rats. Neurosci Lett 2004, 372:40-45. Savas S, Delibas N, Savas C, Sutcu R, Cindas A: Pentoxifylline reduces biochemical markers of ischemia-reperfusion induced spinal cord injury in rabbits. Spinal Cord 2002, 40:224-229.Authors’ contributionsLi-Hong Fan carried out all in vivo studies, participated in the design of the study and contributed to manuscript preparation. Kun-Zheng Wang assisted in the design of the study, reviewed all data, and assisted in writing the manuscript. Bin Cheng assisted in histopathologic analysis and neurological testing. Chun-Sheng Wang performed all the statistical analysis. Xiao-Qian Dang helped the design of the study and participated in writing the manuscript. All authors have read and approved the final manuscript.2. 3. 4.5. 6. 7. 8. 9.Additional material Additional FilePysiologic Variables MABP: mean arterial blood pressure; RT: rectal temperature; BG: blood glucose level. There were no statistically significant purchase EPZ004777 differences in any physiological parameters between the groups. Click.
