Product Name :
CDK12-IN-3
Description:
CDK12-IN-3 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay.
CAS:
2220184-50-7
Molecular Weight:
470.52
Formula:
C23H28F2N8O
Chemical Name:
2-[(2S)-1-(6-[(6,7-difluoro-1H-1,3-benzodiazol-2-yl)methyl]amino-9-(propan-2-yl)-9H-purin-2-yl)piperidin-2-yl]ethan-1-ol
Smiles :
CC(C)N1C=NC2C1=NC(=NC=2NCC1NC2=C(C=CC(F)=C2F)N=1)N1CCCC[C@H]1CCO
InChiKey:
KULPPFCRBINTBS-AWEZNQCLSA-N
InChi :
InChI=1S/C23H28F2N8O/c1-13(2)33-12-27-20-21(26-11-17-28-16-7-6-15(24)18(25)19(16)29-17)30-23(31-22(20)33)32-9-4-3-5-14(32)8-10-34/h6-7,12-14,34H,3-5,8-11H2,1-2H3,(H,28,29)(H,26,30,31)/t14-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Lycorine Protocol
Shelf Life:
≥12 months if stored properly.Escitalopram manufacturer
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CDK12-IN-3 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay.|Product information|CAS Number: 2220184-50-7|Molecular Weight: 470.PMID:32491803 52|Formula: C23H28F2N8O|Chemical Name: 2-[(2S)-1-(6-[(6,7-difluoro-1H-1,3-benzodiazol-2-yl)methyl]amino-9-(propan-2-yl)-9H-purin-2-yl)piperidin-2-yl]ethan-1-ol|Smiles: CC(C)N1C=NC2C1=NC(=NC=2NCC1NC2=C(C=CC(F)=C2F)N=1)N1CCCC[C@H]1CCO|InChiKey: KULPPFCRBINTBS-AWEZNQCLSA-N|InChi: InChI=1S/C23H28F2N8O/c1-13(2)33-12-27-20-21(26-11-17-28-16-7-6-15(24)18(25)19(16)29-17)30-23(31-22(20)33)32-9-4-3-5-14(32)8-10-34/h6-7,12-14,34H,3-5,8-11H2,1-2H3,(H,28,29)(H,26,30,31)/t14-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (531.33 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CDK12-IN-3 is a highly selective CDK12 inhibitor profiled across a panel of 352 kinases at 0.1 µM. CDK12-IN-3 shows potent inhibition of phosphorylation of Ser2 on the CTD repeat domain of RNA Pol II as well as growth inhibition of OV90 cells and acute cytotoxicity to THP1 cells.|Products are for research use only. Not for human use.|
