Product Name :
BI8626
Description:
BI8626 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 0.9 μM.
CAS:
1875036-75-1
Molecular Weight:
440.54
Formula:
C25H28N8
Chemical Name:
N-{[3-(aminomethyl)phenyl]methyl}-8-(4-benzylpiperazin-1-yl)-[1,3]diazino[5,4-d]pyrimidin-4-amine
Smiles :
NCC1=CC(CNC2=NC=NC3C2=NC=NC=3N2CCN(CC3C=CC=CC=3)CC2)=CC=C1
InChiKey:
DZDNGSNKWIORRZ-UHFFFAOYSA-N
InChi :
InChI=1S/C25H28N8/c26-14-20-7-4-8-21(13-20)15-27-24-22-23(29-17-30-24)25(31-18-28-22)33-11-9-32(10-12-33)16-19-5-2-1-3-6-19/h1-8,13,17-18H,9-12,14-16,26H2,(H,27,29,30)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BI8626 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 0.9 μM.|Product information|CAS Number: 1875036-75-1|Molecular Weight: 440.54|Formula: C25H28N8|Chemical Name: N-{[3-(aminomethyl)phenyl]methyl}-8-(4-benzylpiperazin-1-yl)-[1,3]diazino[5,4-d]pyrimidin-4-amine|Smiles: NCC1=CC(CNC2=NC=NC3C2=NC=NC=3N2CCN(CC3C=CC=CC=3)CC2)=CC=C1|InChiKey: DZDNGSNKWIORRZ-UHFFFAOYSA-N|InChi: InChI=1S/C25H28N8/c26-14-20-7-4-8-21(13-20)15-27-24-22-23(29-17-30-24)25(31-18-28-22)33-11-9-32(10-12-33)16-19-5-2-1-3-6-19/h1-8,13,17-18H,9-12,14-16,26H2,(H,27,29,30)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.{{Lanosterol} medchemexpress|{Lanosterol} Endogenous Metabolite|{Lanosterol} Purity & Documentation|{Lanosterol} Description|{Lanosterol} supplier|{Lanosterol} Epigenetics} 33 mg/mL (189.{{Esaxerenone} medchemexpress|{Esaxerenone} Mineralocorticoid Receptor|{Esaxerenone} Protocol|{Esaxerenone} Formula|{Esaxerenone} custom synthesis|{Esaxerenone} Autophagy} 15 mM; Need ultrasonic).PMID:32833131 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|BI8626 induces HUWE1 ectopically expresses to abolishe ubiquitination of MCL1 in HeLa cells. BI8626 suppresses colony formation of Ls174T cells with estimated IC50 value of 0.7 μM, and BI8622 (1-4 days) treatment retards passage of Ls174T cells through all phases of the cell cycle, with the effect being strongest for G1. BI8626 (0-50 μM; 0-6 hours) retards the degradation of MCL1 in response to UV irradiation to the same extent as depletion of HUWE1 in U2OS cells.|Products are for research use only. Not for human use.|
