Product Name :
KZR-504
Description:
KZR-504 is a highly selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2), with IC50s of 51 nM, 4.274 μM for LMP2 and LMP7, respectively. KZR-504 is of interest for the treatment of autoimmune disease.
CAS:
1629052-78-3
Molecular Weight:
413.42
Formula:
C21H23N3O6
Chemical Name:
(2S)-3-hydroxy-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(6-oxo-1,6-dihydropyridin-2-yl)formamido]propanamide
Smiles :
C[C@@]1(CO1)C(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)C1=CC=CC(=O)N1
InChiKey:
QYDASSGXBXGRBS-CKJXQJPGSA-N
InChi :
InChI=1S/C21H23N3O6/c1-21(12-30-21)18(27)15(10-13-6-3-2-4-7-13)23-20(29)16(11-25)24-19(28)14-8-5-9-17(26)22-14/h2-9,15-16,25H,10-12H2,1H3,(H,22,26)(H,23,29)(H,24,28)/t15-,16-,21+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Edoxaban} site|{Edoxaban} Metabolic Enzyme/Protease|{Edoxaban} Protocol|{Edoxaban} Data Sheet|{Edoxaban} supplier|{Edoxaban} Epigenetic Reader Domain}
Additional information:
KZR-504 is a highly selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2), with IC50s of 51 nM, 4.{{Telmisartan} MedChemExpress|{Telmisartan} Autophagy|{Telmisartan} Technical Information|{Telmisartan} In stock|{Telmisartan} supplier|{Telmisartan} Epigenetic Reader Domain} 274 μM for LMP2 and LMP7, respectively.PMID:24013184 KZR-504 is of interest for the treatment of autoimmune disease.|Product information|CAS Number: 1629052-78-3|Molecular Weight: 413.42|Formula: C21H23N3O6|Chemical Name: (2S)-3-hydroxy-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(6-oxo-1,6-dihydropyridin-2-yl)formamido]propanamide|Smiles: C[C@@]1(CO1)C(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)C1=CC=CC(=O)N1|InChiKey: QYDASSGXBXGRBS-CKJXQJPGSA-N|InChi: InChI=1S/C21H23N3O6/c1-21(12-30-21)18(27)15(10-13-6-3-2-4-7-13)23-20(29)16(11-25)24-19(28)14-8-5-9-17(26)22-14/h2-9,15-16,25H,10-12H2,1H3,(H,22,26)(H,23,29)(H,24,28)/t15-,16-,21+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 170 mg/mL (411.20 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Evaluating the inhibition of LMP2, and antitargets LMP7 and β5, in mouse tissues reveals that KZR-504 (compound 12) is both selective and potent in vivo with >50% target inhibition achieved at >1 mg/kg in all tissues tested except brain.|Products are for research use only. Not for human use.|
