Product Name :
Trk-IN-4
Description:
Trk-IN-4 (PF-6683324 isomer) is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect.
CAS:
1799788-94-5
Molecular Weight:
521.46
Formula:
C24H23F4N5O4
Chemical Name:
2-{[(3S,4R)-3-fluoro-1-{2-[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide
Smiles :
CN1C=C(N=C1)C1=CC(=C(N=C1)O[C@@H]1CCN(C[C@@H]1F)C(=O)CC1C=CC(=CC=1)OC(F)(F)F)C(N)=O
InChiKey:
XJIIVPVOGYFVME-AZUAARDMSA-N
InChi :
InChI=1S/C24H23F4N5O4/c1-32-12-19(31-13-32)15-9-17(22(29)35)23(30-10-15)36-20-6-7-33(11-18(20)25)21(34)8-14-2-4-16(5-3-14)37-24(26,27)28/h2-5,9-10,12-13,18,20H,6-8,11H2,1H3,(H2,29,35)/t18-,20+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Trk-IN-4 (PF-6683324 isomer) is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect.|Product information|CAS Number: 1799788-94-5|Molecular Weight: 521.46|Formula: C24H23F4N5O4|Chemical Name: 2-{[(3S,4R)-3-fluoro-1-{2-[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide|Smiles: CN1C=C(N=C1)C1=CC(=C(N=C1)O[C@@H]1CCN(C[C@@H]1F)C(=O)CC1C=CC(=CC=1)OC(F)(F)F)C(N)=O|InChiKey: XJIIVPVOGYFVME-AZUAARDMSA-N|InChi: InChI=1S/C24H23F4N5O4/c1-32-12-19(31-13-32)15-9-17(22(29)35)23(30-10-15)36-20-6-7-33(11-18(20)25)21(34)8-14-2-4-16(5-3-14)37-24(26,27)28/h2-5,9-10,12-13,18,20H,6-8,11H2,1H3,(H2,29,35)/t18-,20+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Fruquintinib} site|{Fruquintinib} VEGFR|{Fruquintinib} Biological Activity|{Fruquintinib} In Vitro|{Fruquintinib} custom synthesis|{Fruquintinib} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.{{PDGF-AA Protein, Human} site|{PDGF-AA Protein, Human} Biological Activity|{PDGF-AA Protein, Human} In stock|{PDGF-AA Protein, Human} custom synthesis|{PDGF-AA Protein, Human} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:34856019 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Trk-IN-4 (Compound 10b) exhibits superb Trk selectivity with >95% inhibition of TrkA and >40% inhibition of only 1 other kinase VEGFR2 (cell-based assay for VEGFR2 IC50>5 μM).|Products are for research use only. Not for human use.|
