Product Name :
Solcitinib
Description:
Solcitinib, also known as GSK2586184 or GLPG0778, is a Janus kinase 1 (JAK1) inhibitor. Solcitinib may be potential useful for treatment of psoriasis，systemic lupus erythematosus, ulcerative colitis.
CAS:
1206163-45-2
Molecular Weight:
389.45
Formula:
C22H23N5O2
Chemical Name:
N-(5-(4-(3,3-dimethylazetidine-1-carbonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide
Smiles :
CC1(C)CN(C1)C(=O)C1C=CC(=CC=1)C1=CC=CC2=NC(NC(=O)C3CC3)=NN21
InChiKey:
MPYACSQFXVMWNO-UHFFFAOYSA-N
InChi :
InChI=1S/C22H23N5O2/c1-22(2)12-26(13-22)20(29)16-10-6-14(7-11-16)17-4-3-5-18-23-21(25-27(17)18)24-19(28)15-8-9-15/h3-7,10-11,15H,8-9,12-13H2,1-2H3,(H,24,25,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{EIPA} web|{EIPA} Na+/H+ Exchanger (NHE)|{EIPA} Purity & Documentation|{EIPA} In stock|{EIPA} manufacturer|{EIPA} Epigenetics}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Solcitinib, also known as GSK2586184 or GLPG0778, is a Janus kinase 1 (JAK1) inhibitor. Solcitinib may be potential useful for treatment of psoriasis，systemic lupus erythematosus, ulcerative colitis.|Product information|CAS Number: 1206163-45-2|Molecular Weight: 389.45|Formula: C22H23N5O2|Synonym:|GSK-2586184|GSK-2586184A|GLPG-0778|G154578|GSK2586184|GSK 2586184|GSK2586184A|GSK 2586184A|GLPG 0778|GLPG0778|Solcitinib|Chemical Name: N-(5-(4-(3,3-dimethylazetidine-1-carbonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide|Smiles: CC1(C)CN(C1)C(=O)C1C=CC(=CC=1)C1=CC=CC2=NC(NC(=O)C3CC3)=NN21|InChiKey: MPYACSQFXVMWNO-UHFFFAOYSA-N|InChi: InChI=1S/C22H23N5O2/c1-22(2)12-26(13-22)20(29)16-10-6-14(7-11-16)17-4-3-5-18-23-21(25-27(17)18)24-19(28)15-8-9-15/h3-7,10-11,15H,8-9,12-13H2,1-2H3,(H,24,25,28)|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO, not in water|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Agmatine} site|{Agmatine} Neuronal Signaling|{Agmatine} Protocol|{Agmatine} References|{Agmatine} custom synthesis|{Agmatine} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:23715856 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|Solcitinib is an orally active, competitive, potent, selective JAK1 inhibitor, with an IC50 of 9.8 nM, and 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively. Solcitinib is used in the research of moderate-to-severe plaque-type psoriasis.|References:|Ludbrook VJ, et al. Investigation of selective JAK1 inhibitor GSK2586184 for the treatment of psoriasis in a randomized placebo-controlled phase IIa study. Br J Dermatol. 2016 May;174(5):985-95.Products are for research use only. Not for human use.|
