Product Name :
KUN79359
Description:
KUN79359, also known as RIP1 kinase inhibitor and PKCß inhibitor, is a potent and selective inhibitor of PKCß isozymes.
CAS:
257879-35-9
Molecular Weight:
411.46
Formula:
C24H21N5O2
Chemical Name:
3-[1-(3-Imidazol-1-yl-propyl)-1H-indol-3-yl]-4-phenylamino-pyrrole-2,5-dione
Smiles :
O=C1NC(=O)C(NC2C=CC=CC=2)=C1C1=CN(CCCN2C=NC=C2)C2=CC=CC=C21
InChiKey:
KIWODJBCHRADND-UHFFFAOYSA-N
InChi :
InChI=1S/C24H21N5O2/c30-23-21(22(24(31)27-23)26-17-7-2-1-3-8-17)19-15-29(20-10-5-4-9-18(19)20)13-6-12-28-14-11-25-16-28/h1-5,7-11,14-16H,6,12-13H2,(H2,26,27,30,31)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
KUN79359, also known as RIP1 kinase inhibitor and PKCß inhibitor, is a potent and selective inhibitor of PKCß isozymes.|Product information|CAS Number: 257879-35-9|Molecular Weight: 411.46|Formula: C24H21N5O2|Synonym:|PKCß inhibitor|RIP1 kinase inhibitor|KUN-79359|KUN79359|Chemical Name: 3-[1-(3-Imidazol-1-yl-propyl)-1H-indol-3-yl]-4-phenylamino-pyrrole-2,5-dione|Smiles: O=C1NC(=O)C(NC2C=CC=CC=2)=C1C1=CN(CCCN2C=NC=C2)C2=CC=CC=C21|InChiKey: KIWODJBCHRADND-UHFFFAOYSA-N|InChi: InChI=1S/C24H21N5O2/c30-23-21(22(24(31)27-23)26-17-7-2-1-3-8-17)19-15-29(20-10-5-4-9-18(19)20)13-6-12-28-14-11-25-16-28/h1-5,7-11,14-16H,6,12-13H2,(H2,26,27,30,31)|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|KUN79359 (0-30 μM; 48 hours) suppresses tumor cell proliferation in a time- and dose-dependent manner. KUN79359 (14 μM; 2-48 hours) induces apoptosis in 2F7 cells. KUN79359 (15 μM; 2-48 hours) inhibits cell cycle progression in 2F7 and BCBL-1 cells. KUN79359 (15 or 14 μM, respectively; 2-48 hours) inhibitor 1 reduces the expression of phospho-PKCβ in BCBL-1 and 2F7 cells. KUN79359 (0-48 hours) suppresses GSK3β, mTOR, and S6 phosphorylation.|References:|Pakhomov N, Pustovit K, Potekhina V, Filatova T, Kuzmin V, Abramochkin D. Negative inotropic effects of diadenosine tetraphosphate are mediated by protein kinase C and phosphodiesterases stimulation in the rat heart.{{Alogliptin} site|{Alogliptin} Ferroptosis|{Alogliptin} Biological Activity|{Alogliptin} In Vivo|{Alogliptin} custom synthesis|{Alogliptin} Autophagy} Eur J Pharmacol.{{Dobutamine} medchemexpress|{Dobutamine} Adrenergic Receptor|{Dobutamine} Purity & Documentation|{Dobutamine} Data Sheet|{Dobutamine} manufacturer|{Dobutamine} Cancer} 2017 Dec 9.PMID:24065671 pii: S0014-2999(17)30818-X. doi: 10.1016/j.ejphar.2017.12.024. [Epub ahead of print] PubMed PMID: 29233660.Campana M, Bellini L, Rouch C, Rachdi L, Coant N, Butin N, Bandet CL, Philippe E, Meneyrol K, Kassis N, Dairou J, Hajduch E, Colsch B, Magnan C, Le Stunff H. Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats. Mol Metab. 2017 Nov 7. pii: S2212-8778(17)30690-7. doi: 10.1016/j.molmet.2017.10.013. [Epub ahead of print] PubMed PMID: 29233519.Lu T, Chou CT, Liang WZ, Kuo CC, Chen IL, Wang JL, Jan CR. Amitriptyline modulated Ca(2+) signaling and induced Ca(2+)-independent cell viability in human osteosarcoma cells. Hum Exp Toxicol. 2017 Jan 1:960327117693070. doi: 10.1177/0960327117693070. [Epub ahead of print] PubMed PMID: 29233021.Products are for research use only. Not for human use.|
