Product Name :
Cetilistat
Description:
Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM, and 5.95 nM, respectively.
CAS:
282526-98-1
Molecular Weight:
401.58
Formula:
C25H39NO3
Chemical Name:
2-(hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one
Smiles :
CC1C=C2C(=CC=1)N=C(OC2=O)OCCCCCCCCCCCCCCCC
InChiKey:
MVCQKIKWYUURMU-UHFFFAOYSA-N
InChi :
InChI=1S/C25H39NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-19-28-25-26-23-18-17-21(2)20-22(23)24(27)29-25/h17-18,20H,3-16,19H2,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM, and 5.95 nM, respectively.|Product information|CAS Number: 282526-98-1|Molecular Weight: 401.58|Formula: C25H39NO3|Chemical Name: 2-(hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one|Smiles: CC1C=C2C(=CC=1)N=C(OC2=O)OCCCCCCCCCCCCCCCC|InChiKey: MVCQKIKWYUURMU-UHFFFAOYSA-N|InChi: InChI=1S/C25H39NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-19-28-25-26-23-18-17-21(2)20-22(23)24(27)29-25/h17-18,20H,3-16,19H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{SNDX-5613} MedChemExpress|{SNDX-5613} Epigenetic Reader Domain|{SNDX-5613} Purity & Documentation|{SNDX-5613} Data Sheet|{SNDX-5613} manufacturer|{SNDX-5613} Epigenetic Reader Domain} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Cetilistat inhibits rat pancreatic lipase activity with an IC50 of 54.{{Tetrahydrocurcumin} medchemexpress|{Tetrahydrocurcumin} Autophagy|{Tetrahydrocurcumin} Technical Information|{Tetrahydrocurcumin} References|{Tetrahydrocurcumin} custom synthesis|{Tetrahydrocurcumin} Epigenetics} 8 nM.PMID:23558135 Also, Cetilistat inhibits human pancreatic lipase activity with an IC50 of 5.95 nM, which is 9.2 times more potent than for rat pancreatic lipase.|In Vivo:|Cetilistat (3, 10, 30, or 100 mg/kg) reduces intestinal fat absorption by inhibiting pancreatic lipase activity in male SD rats. Cetilistat (4.9, 14.9, or 50.7 mg/kg; mixed into powdered high-fat diet; once a day; for three weeks) shows anti-obesity and antihyperlipidemic effects on DIO F344 rats by reducing intestinal fat absorption.|Products are for research use only. Not for human use.|
