rolinska Institutet, Stockholm, Sweden; 2Karolinska UniversityHospital, Stockholm, Sweden; 3Danderyds Sjukhus, Stockholm, Sweden PB1184|Diagnostic Accuracy of D-dimer for Splanchnic Vein Thrombosis: A Systematic Assessment and Meta-analysis L.M. Attard1; K. Vella1; N. Riva1; J. Calleja Agius1; A. Gatt1; A. SquizzatoBackground: Pulmonary embolism (PE) can be a typical and potentially life-threatening condition. V/Q SPECT is one of the diagnostic procedures, but inconclusive benefits are causing issues inside the clinical setting. Aims: To analyze the additional diagnostic workup and also the initiation or transform of anticoagulation treatment just after an inconclusive V/Q SPECT in patients with suspected pulmonary embolism (PE). Approaches: A retrospective evaluation of electronic medical records was made for all individuals with suspected PE who underwent V/Q SPECT 2014019 at two teaching hospitals. The frequency of further imaging with Caspase 2 Inhibitor Gene ID computed tomography pulmonary angiography (CTPA) plus the resulting anticoagulation therapy (ACT) of patients was analyzed. Benefits: A total of 865 sufferers with suspected PE have been included, 574 acute and 291 chronic PE. 502 female and 363 male, age 199 years (mean 65, SD 19) for both groups. There have been 131 (15 ) constructive and 568 (66 ) negative cases for PE of V/Q SPECT. The remaining 166 cases (19 ) had an inconclusive outcome. 20 (n = 112) inside the acute and 19 (n = 54) in the chronic PE group. Inside the group with suspected acute PE and inconclusive V/Q SPECT result, only 9 (n = ten) underwent additional diagnostics with CTPA, which had been all damaging. On the remaining 102 individuals, ten (n = 10) were already on a longterm therapeutic dose of ACT. 14 (n = 14) have been started on ACT and 76 (n = 78) did not obtain any ACT. See the figure for the chronic PE group.University of Malta, Msida, Malta; 2University of Insubria Departmentof Medicine and Surgery, Varese/Como, Italy Background: D-dimer is integrated within the diagnostic algorithm for deep vein thrombosis in the decrease limbs and pulmonary embolism. Nevertheless, its role for the diagnosis of splanchnic vein thrombosis (SVT) continues to be debated, specifically thinking about that quite a few circumstances predisposing to SVT are related with enhanced D-dimer (malignancy, IL-23 Inhibitor Storage & Stability abdominal surgery, liver cirrhosis). Aims: To evaluate the accuracy of D-dimer inside the diagnosis of SVT by performing a systematic evaluation on the literature and meta-analysis. Strategies: The protocol of this systematic review was registered a priori in PROSPERO (CRD42020184300). We performed a bibliographic search inside the electronic databases MEDLINE, EMBASE, and CENTRAL up to July 2020, in order to determine all studies which evaluated D-dimer accuracy in individuals with suspected SVT. The index test was any D-dimer assay. The reference regular was radiological imaging (abdominal ultrasound, computed tomography, magnetic resonance, angiography) or abdominal surgery. The QUADAS-2 checklist was employed for the threat of bias assessment. We calculated pooled weighted mean specificity/sensitivity and positive/negative likelihood ratios. Final results: Among the 11 incorporated research, 9 enrolled only cirrhotic patients (five of them post-surgery). Risk of bias was higher in 9 research.868 of|ABSTRACTconfirmed by CT angiography in all the individuals, when DVT was confirmed by ultrasound in 34 patients. Study population was followed up for 9.7 months. Multivariate regression evaluation was done exactly where proper ventricular (RV) diameter (imply 3.74 cm), imply PASP (66 23 mm Hg), RV hyp
