S, epidemiological studies to detect associations of gene polymorphisms with disease phenotypes are desired.
HHS Public AccessAuthor manuscriptBiochim Biophys Acta. Author manuscript; offered in PMC 2016 April 01.Published in final edited type as: Biochim Biophys Acta. 2015 April ; 1855(2): 27600. doi:10.1016/j.bbcan.2015.03.006.Author Manuscript Author Manuscript Author Manuscript Author ManuscriptInsights in to the important roles of proteoglycans in breast cancer Caspase 4 MedChemExpress biology and translational medicineAchilleas D. Theocharis1, Spyros S. Skandalis1, Thomas Neill2, Hinke A. B. Multhaupt3, Mario Hubo4, Helena Frey4, Sandeep Gopal3, Ang ica Gomes3, Nikos Afratis3, Hooi Ching Lim3, John R. Couchman3, Jorge Filmus5, Ralph D. Sanderson6, Liliana Schaefer4, Renato V. Iozzo2, and Nikos K. Karamanos1,1Biochemistry,Biochemical Analysis Matrix Pathobiology Research Group, Laboratory of Biochemistry, Division of Chemistry, University of Patras, 26500 Patras, Greece2Departmentof Pathology, Anatomy and Cell Biology, and also the Cancer Cell Biology and Signaling System, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA of Biomedical Sciences and Biotech Research Innovation Center, University of Copenhagen, Denmark3Department4Universityof Frankfurt, Institute of Pharmacology and Toxicology, Theodor-Stern Kai 7, Frankfurt 60590 Germany of Biological Sciences, Sunnybrook Study Institute and Division of Medical Biophysics, University of Toronto, Canada6University5Departmentof Alabama at Birmingham, Department of Pathology, UAB Comprehensive Cancer Center, 1720 2nd Ave. S, WTI 602B, Birmingham, AL 35294, USAAbstractProteoglycans manage several regular and pathological processes, among that are morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. In the course of tumor improvement and growth, proteoglycan expression is markedly modified inside the tumor microenvironment. Altered expression of proteoglycans on tumor and stromal cell membranes impacts cancer cell signaling, development and survival, cell adhesion, migration and angiogenesis. Despite the high complexity and heterogeneity of breast cancer, the fast evolution in our know-how that proteoglycans are amongst the key players in the breast tumor microenvironment suggests their potential as pharmacological targets within this type of cancer. It has been lately recommended that pharmacological treatment may target proteoglycan metabolism, their utilization as targets for immunotherapy or their direct use as therapeutic agents. The diversity inherent inside the proteoglycans that can be presented herein supplies the possible for a number of layers of regulation2015 Published by Elsevier B.V. Corresponding author: Nikos K. Karamanos, address as above, telephone: +30-2610-997915, [email protected]. Publisher’s Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our consumers we’re supplying this early version from the manuscript. The manuscript will undergo copyediting, typesetting, and assessment on the resulting proof just before it really is published in its final citable kind. Please note that throughout the production process errors may well be 5-HT5 Receptor Purity & Documentation discovered which could have an effect on the content material, and all legal disclaimers that apply towards the journal pertain.Theocharis et al.Pageof breast tumor behavior. This assessment summarizes current developments concerning the biology of selected proteoglycans in breast cancer, and presents prospective.
