Tions. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in elevated platelet production. Additionally promotes the proliferation of hepatocytes in UCB-5307 supplier response to liver damage. Cytokine using a wide selection of biological functions in immunity, tissue regeneration, and metabolism. Potent inducer from the acute phase response. Chemokine that binds the receptor CCR2 and induces the chemoattraction of mononuclear cells. Induces the activation of monocytes, NK cells, lymphocytes, and basophils. Chemokine having a principal role within the inflammatory immune response by way of its capability to chemoattract leukocytes and modulate their function. CXC chemokine with pro-inflammatory effects, involved in angiogenesis. Pleiotropic cytokine. Induces the hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, as well as the stimulation of acute-phase protein synthesis in hepatocytes. Member of the leukemia inhibitory factor/oncostatin-M family members of proteins. Regulates cytokine production. 1.6 two.07 FC Day 7 Z/C 0.55 FC Day 21 Z/C 0.LeptinLEPResistin Serpin ARETN SERPINA1.55 0.0.81 11.VisfatinNAMPT0.0.MIF TNF BAFF/BLyS/TNFSF13B1.29 0.58 0.0.8 0.13 0.Interleukin 1 BetaIL-1B0.1.InterleukinIL-0.0.InterleukinIL-0.1.Interleukin six C-C Motif Chemokine Ligand 2 C-C Motif Chemokine Ligand five C-X-C Motif Chemokine Ligand eight Leukemia Inhibitory Element Interleukin six Family Cytokine Oncostatin MIL-0.1.CCL2/MCP-0.0.CCL5/RANTES1.1.CXCL8/IL-0.0.LIF0.0.OSM0.0.Toxins 2021, 13,7 ofTable 1. Cont. Protein Name Symbol Description Inflammation-related proteins Member in the pentraxin loved ones of proteins. Sensor and activator on the innate immune response. The amount of this protein in plasma increases significantly during acute phase response to tissue injury, infection, or other inflammatory stimuli. Calcium-, zinc-, and copper-binding protein using a part within the regulation of inflammatory processes and immune response. Iron-trafficking protein involved in several processes for instance apoptosis, innate immunity, and renal improvement. Transports smaller hydrophobic molecules including lipids, steroid hormones, and retinoids. Heme protein, component from the host defense method of polymorphonuclear leukocytes. Member in the pentraxin family of proteins. Acts as a pattern recognition receptor with roles in the innate immune response to numerous microbes. Overexpression results in enhanced pro-inflammatory responses. Cathepsins Cathepsin D CTSD Enzyme with pepsin-like activity. Plays a role in protein turnover and in the proteolytic activation of AZD4625 Biological Activity hormones and growth elements. Lysosomal cysteine protease. Hydrolyzes several proteins, including the proform of urokinase-type plasminogen activator. Lysosomal cysteine protease on the papain family. Essential protease accountable for the removal in the invariant chain from significant histocompatibility complicated (MHC) class II molecules and MHC class II antigen presentation. Angiopoietins Angiopoietin-1 Angiopoietin-2 Angiopoietin-like 2 Angiopoietin-like 3 ANGPT1 ANGPT2 ANGPTL2 ANGPTL3 Binds the Tie-2 receptor tyrosine kinase. Critical modulator of angiogenesis. Member with the angiopoietin family members. Upregulated in several inflammatory diseases. Implicated in the direct manage of inflammation-related signaling pathways. Binds the Tie-2 receptor tyrosine kinase. Significant modulators of angiogenesis. Binds the Tie-2 receptor tyrosine kin.
