Act of emergency capsule enteroscopy in severe obscureovert gastrointestinal bleeding. Endoscopy ; Apr: . . Apostolopoulos P,Liatsos C,Gralnek IM,et al. Evaluation of capsule endoscopy in active,mildtomoderate,overt,obscure GI bleeding. Gastrointest Endosc ; Dec: . . PintoPais T,Pinho R,Rodrigues A,et al. Emergency singleballoon enteroscopy in overt obscure gastrointestinal bleeding: efficacy and safety. United European Gastroenterol J ; Dec: . Disclosure of Interest: None declaredP PREDICTING INFLAMMATORY PATHOLOGY AT CAPSULE ENTEROSCOPY: What is the UTILITY OF A RAISED FAECAL CALPROTECTINC. Parker,C. Lamb,M. Robinson,J. Mansfield,M. Gunn Gastroenterology,Royal Victoria Infirmary,Newcastle upon Tyne,United KingdomContact E-mail Address: clare.e.parkerdoctors.net.uk Introduction: Faecal Calprotectin (FCP) is usually a broadly employed biomarker of gastrointestinal (GI) mucosal inflammation. Several capsule enteroscopy (CE) services are receiving elevated referrals of individuals with abdominal symptoms combined with an elevated FCP (mgg) but regular gastroscopy,colonoscopy or radiology. There is tiny information on applying FCP levels as a screening tool for selecting sufferers in whom CE will cause a definitive diagnosis. Elevated FCP levels may indiscriminately drive investigations in endoscopy and imagingnegative individuals who subsequently have standard findings at CE. We aimed to identify the incidence of inflammatory pathology on CE in patients using a raised FCP,and if a suitable concentration of your biomarker might be identified as a screening tool to prevent unnecessary CE. Aims Strategies: A single centre retrospective Cecropin B web assessment of the Newcastle upon Tyne Hospitals CE database was carried out (Feb Feb. Patients PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25611386 with GI symptoms (abdominal pain,diarrhoea,bloating,vomiting,fat reduction) along with a raised FCP (mgg) had been identified. Findings at CE considered to be inflammatory have been: erythema,ulceration,erosions and fissuring. Benefits: patients had been identified with elevated FCP and GI symptoms. . (n) had inflammation identified by CE and in . (n) no inflammatory pathology was identified. The imply (SE) FCP was higher in individuals with evidence of inflammation at CE in comparison to these with no inflammation: .mgg vs. mgg; p Stratifying patients based on FCP revealed that only . of patients (n) with a FCP of mgg had inflammatory findings at CE. This rose to . of sufferers (n) with a FCP of mgg,and . of patients (n) having a FCP mgg. A threshold of mgg FCP revealed a sensitivity of . to predict inflammation at CE,with a specificity of . . This FCP threshold had a damaging predictive worth of . ,and optimistic predictive worth of . for CE inflammation. Conclusion: In this small retrospective evaluation of a subgroup of individuals referred for CE using a FCP of mgg the likelihood of identifying inflammatory pathology at CE increased with increasing FCP concentrations above mgg. A threshold of mgg supplied a higher unfavorable predictive value for CE inflammation and may well be a valuable screening tool to lower the requirement for CE in choose patient groups. This retrospective analysis ought to be confirmed in a larger prospective cohort. Disclosure of Interest: None declaredUnited European Gastroenterology Journal (S) P Part OF SECONDGENERATION COLON ENDOSCOPY FOR Whole GUT EVALUATION CAPSULEA Final results: patients have been enrolled for the final investigation ( cases were excluded from further analysis due to the capsule did not attain the colon). In individuals 1 or much more lesions previously missed by conv.
