Se of clinical details, diagnoses had been grouped as outlined by the Expanded Diagnostic Clusters (EDC) of the ACGsystem. To thisPoblador-Plou et al. BMC Psychiatry , : http:biomedcentral-XPage ofThis technique, also to identifying associations between groups of variables, allows exactly the same variable to grow to be element of numerous components. Similar for the logistic regression models, only illnesses with a prevalence of had been incorporated for every study group. Aspect evaluation was primarily based on tetrachoric correlation matrices , and also the variables were extracted using the principal element system. The amount of aspects to become extracted was determined making use of scree plots plus the clinical evaluation from the unique solutions obtained. The sampling adequacy was analyzed making use of the Kaiser-Meyer-Olkin (KMO) parameter, and also the cumulative fraction of total variance was applied as a measure in the model’s goodness of match. EDCs having a element score larger thanwere chosen, together with the aim of determining the illnesses that composed every single pattern. STATAsoftware was applied for the statistical analyses, and Excel was made use of to create the corresponding graphs.Prevalence of comorbiditiesA total of various comorbidities using a prevalence of have been identified within the population with dementia (unique comorbidities in men and in women). The ailments with all the highest prevalence for each sexes had been hypertension, anxiety and neurosis, degenerative joint illness, lipid metabolism disorders, reduce back discomfort, diabetes, anemia, thyroid illness, cataracts and aphakia, and cardiac arrhythmia (Table)orbidities extracted from several logistic regression analysisAnxiety and neurosis in males (OR, CI, .-.) and chronic skin ulcers in females (OR, CI, .-.) had been the illnesses using the highest dementiaassociation probability. Of your comorbidities discovered to be drastically connected with dementia, seven occurred in both guys and females (anxiety and neurosis, Parkinson’s illness, chronic skin ulcers, anemia, purchase ACT-334441 cerebrovascular illness, cardiac arrhythmia and thyroid illness; Table).Exploratory element analysisResults The studied population consisted of , patients, of whom , were diagnosed with dementia. The Paprotrain chemical information frequency of dementia in girls was more than double that in men (Table). PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/15692103?dopt=Abstract Sufferers with dementia were, on typical, four years older than these devoid of the index illness (vs. years). Amongst the individuals with dementia,had dementia because the only diagnosis,showed at the least two comorbidities andshowed at least 3. The average number of comorbidities in the population with dementia (. in men andin females) was substantially higher than in the population not diagnosed with dementia (. in men andin females).Table Study populationThe aspect evaluation for the whole population more than permitted the identification of three illness patterns in men, formed by an typical of eight ailments. Dementia was present in only one particular pattern (Pattern) in conjunction with congestive heart failure, anemia, Parkinson’s illness, behavioral troubles, chronic skin ulcers, cerebrovascular disease and osteoporosis (Figure). 4 disease patterns have been 
identified in ladies, formed by an typical of six ailments. As with guys, dementia was present only within a single pattern (Pattern) associated with congestive heart failure, cardiac arrhythmia, anemia, cerebrovascular illness and chronic skin ulcers (Figure). As a result, only four ailments have been identified (congestive heart failure, anemia, chronic skin ulcers andPatients without dementia Total n Imply age (SD) Variety of d.Se of clinical facts, diagnoses have been grouped based on the Expanded Diagnostic Clusters (EDC) on the ACGsystem. To thisPoblador-Plou et al. BMC Psychiatry , : http:biomedcentral-XPage ofThis process, additionally to identifying associations amongst groups of variables, permits exactly the same variable to come to be part of several factors. Similar for the logistic regression models, only ailments using a prevalence of had been incorporated for every single study group. Factor analysis was based on tetrachoric correlation matrices , and the variables have been extracted employing the principal aspect process. The number of aspects to become extracted was determined using scree plots and also the clinical evaluation on the distinctive solutions obtained. The sampling adequacy was analyzed applying the Kaiser-Meyer-Olkin (KMO) parameter, along 
with the cumulative fraction of total variance was utilized as a measure on the model’s goodness of match. EDCs with a issue score higher thanwere chosen, together with the aim of determining the ailments that composed each pattern. STATAsoftware was used for the statistical analyses, and Excel was employed to create the corresponding graphs.Prevalence of comorbiditiesA total of unique comorbidities with a prevalence of have been identified within the population with dementia (distinct comorbidities in guys and in women). The diseases with all the highest prevalence for both sexes had been hypertension, anxiety and neurosis, degenerative joint disease, lipid metabolism problems, reduced back pain, diabetes, anemia, thyroid illness, cataracts and aphakia, and cardiac arrhythmia (Table)orbidities extracted from many logistic regression analysisAnxiety and neurosis in guys (OR, CI, .-.) and chronic skin ulcers in females (OR, CI, .-.) were the illnesses using the highest dementiaassociation probability. In the comorbidities identified to become significantly associated with dementia, seven occurred in each men and women (anxiety and neurosis, Parkinson’s disease, chronic skin ulcers, anemia, cerebrovascular illness, cardiac arrhythmia and thyroid disease; Table).Exploratory issue analysisResults The studied population consisted of , patients, of whom , have been diagnosed with dementia. The frequency of dementia in females was more than double that in males (Table). PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/15692103?dopt=Abstract Sufferers with dementia were, on average, 4 years older than these with out the index illness (vs. years). Among the patients with dementia,had dementia because the only diagnosis,showed at the least two comorbidities andshowed no less than three. The typical quantity of comorbidities inside the population with dementia (. in men andin girls) was considerably greater than within the population not diagnosed with dementia (. in guys andin ladies).Table Study populationThe issue evaluation for the entire population more than permitted the identification of 3 disease patterns in males, formed by an typical of eight ailments. Dementia was present in only one particular pattern (Pattern) in addition to congestive heart failure, anemia, Parkinson’s disease, behavioral complications, chronic skin ulcers, cerebrovascular illness and osteoporosis (Figure). 4 illness patterns were identified in women, formed by an typical of six illnesses. As with males, dementia was present only inside a single pattern (Pattern) related with congestive heart failure, cardiac arrhythmia, anemia, cerebrovascular illness and chronic skin ulcers (Figure). Consequently, only four illnesses have been identified (congestive heart failure, anemia, chronic skin ulcers andPatients without having dementia Total n Mean age (SD) Variety of d.
