Analogue sphygmomanometer. The protocol did not require a period of rest prior to the BP measurements. In the majority of patients, BP was measured once with the subject in the supine position, and then once (all patients) within 3 minutes after standing up. In some patients, the non-standing BP measurements were made in the sitting position (22/80 in the volumetry group, and 60/134 in the semi-quantitative group). For n = 9 patients the non-standing position is unknown. Orthostatic hypotension (OH) was defined according to the Title Loaded From File consensus as a reduction of Title Loaded From File systolic BP of at least 20 mm Hg or diastolic BP of at least 10 mm Hg within 3 minutes of standingOH and WMH in Mild Dementia10 datasets twice; once in the beginning, to secure good inter-rater reliability, and a second time at the end of the editing process, to secure that similar reliability still persisted and to evaluate intrarater reliability. The intraclass correlation coefficient (ICC) was calculated to be 0.998 for inter-rater reliability and 0.964 for intrarater reliability. The manually edited scans were then used in the further analyses of volumes of total and regional WMH. In order to compensate for interindividual differences in total brain volumes, we calculated the ratios of volumes of WMH to total brain volumes, using these in the statistical analyses. In the present study, we used only the ratios of total WMH volumes, which have been shown to be highly correlated with regional WMH volumes [37]. Visual assessment of 1379592 WMH. MRI’s were also rated visually, using the Scheltens scale [38], by an experienced rater (OJG), blind to clinical data. According to the Scheltens scale, white matter changes (WMC) are subdivided into periventricular WMC and deep WMC, and deep WMC are further subdivided into deep WMH (DWMH), basal ganglia WMH (BGH) and infratentorial hyperintensities (IT) [39]. In the statistical analyses, we used only the DWMH scores, because these have been associated with (orthostatic) BP drop in previous studies [15,17]. Inter-rater reliability with another experienced rater (MKB) was evaluated, based on 12 scans, finding an ICC of 0.923.no significant differences between those belonging to the highest and lowest DWMH score quartiles. We did not find any significant association between a history of hypertension and having OH at baseline (Pearson Chi Square 0.224, df 1, p = 0.636).Associations between WMH and OHThere was no significant correlation between WMH volume ratios and the systolic orthostatic BP drops (Spearman’s rho 0.022, p = 0.848), but a trend with diastolic orthostatic BP drops was demonstrated (Spearman’s rho 20.213, p = 0.066). Similarly, we found no significant correlations between DWMH scores and systolic or diastolic orthostatic BP drops (Spearman’s rho 0.037, p = 0.700 and Spearman’s rho 20.122, p = 0.202, respectively). We performed bivariate logistic regression analyses with the variables in Table 2 as predictors, and being in the highest WMH quartile vs. the lowest quartile as response variable. In the volumetry group, age, hypertension, coronary heart disease and APOEe4 status had p-values ,0.25. As to the semi-quantitative group, age, hypertension, APOEe4 status and previous stroke had p-values ,0.25. None of the p-values for the BP variables approached this level, except diastolic BP drop vs. DWMH score (p = 0.297). The aforementioned variables having p-values ,0.25 were entered into stepwise multiple logistic regression analyses. In the fina.Analogue sphygmomanometer. The protocol did not require a period of rest prior to the BP measurements. In the majority of patients, BP was measured once with the subject in the supine position, and then once (all patients) within 3 minutes after standing up. In some patients, the non-standing BP measurements were made in the sitting position (22/80 in the volumetry group, and 60/134 in the semi-quantitative group). For n = 9 patients the non-standing position is unknown. Orthostatic hypotension (OH) was defined according to the consensus as a reduction of systolic BP of at least 20 mm Hg or diastolic BP of at least 10 mm Hg within 3 minutes of standingOH and WMH in Mild Dementia10 datasets twice; once in the beginning, to secure good inter-rater reliability, and a second time at the end of the editing process, to secure that similar reliability still persisted and to evaluate intrarater reliability. The intraclass correlation coefficient (ICC) was calculated to be 0.998 for inter-rater reliability and 0.964 for intrarater reliability. The manually edited scans were then used in the further analyses of volumes of total and regional WMH. In order to compensate for interindividual differences in total brain volumes, we calculated the ratios of volumes of WMH to total brain volumes, using these in the statistical analyses. In the present study, we used only the ratios of total WMH volumes, which have been shown to be highly correlated with regional WMH volumes [37]. Visual assessment of 1379592 WMH. MRI’s were also rated visually, using the Scheltens scale [38], by an experienced rater (OJG), blind to clinical data. According to the Scheltens scale, white matter changes (WMC) are subdivided into periventricular WMC and deep WMC, and deep WMC are further subdivided into deep WMH (DWMH), basal ganglia WMH (BGH) and infratentorial hyperintensities (IT) [39]. In the statistical analyses, we used only the DWMH scores, because these have been associated with (orthostatic) BP drop in previous studies [15,17]. Inter-rater reliability with another experienced rater (MKB) was evaluated, based on 12 scans, finding an ICC of 0.923.no significant differences between those belonging to the highest and lowest DWMH score quartiles. We did not find any significant association between a history of hypertension and having OH at baseline (Pearson Chi Square 0.224, df 1, p = 0.636).Associations between WMH and OHThere was no significant correlation between WMH volume ratios and the systolic orthostatic BP drops (Spearman’s rho 0.022, p = 0.848), but a trend with diastolic orthostatic BP drops was demonstrated (Spearman’s rho 20.213, p = 0.066). Similarly, we found no significant correlations between DWMH scores and systolic or diastolic orthostatic BP drops (Spearman’s rho 0.037, p = 0.700 and Spearman’s rho 20.122, p = 0.202, respectively). We performed bivariate logistic regression analyses with the variables in Table 2 as predictors, and being in the highest WMH quartile vs. the lowest quartile as response variable. In the volumetry group, age, hypertension, coronary heart disease and APOEe4 status had p-values ,0.25. As to the semi-quantitative group, age, hypertension, APOEe4 status and previous stroke had p-values ,0.25. None of the p-values for the BP variables approached this level, except diastolic BP drop vs. DWMH score (p = 0.297). The aforementioned variables having p-values ,0.25 were entered into stepwise multiple logistic regression analyses. In the fina.
